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Alone We Are Rare, but Together We Are Strong: Orphan Diseases Quiz
by Staff
They affect between 420 and 560 million people around the world, yet account for less than 10 percent of global pharmaceutical spending. Take this quiz to see how much you know about conditions known as "orphan" diseases and how they're treated.

Is it true that rare, or "orphan," diseases are typically those the pharmaceutical industry won't profit from?

  • true
  • false

How many people does a disease affect to be considered orphan?

  • 8,000
  • 200,000
  • 25 million

More than 25 million Americans are affected by how many rare diseases?

  • 28,000
  • 20,000
  • 8,000

True or false: Out of about 7,000 diseases, only about 400 have an effective drug therapy.

  • true
  • false

True or false: The plot of two "Quincy, M.E." episodes focused on rare disease awareness.

  • true
  • false

True or false: Actor Jack Klugman testified before Congress in an effort to draw attention to orphan diseases and treatments.

  • true
  • false

What does the Orphan Drug Act of 1983 provide to pharmaceutical companies?

  • facilities
  • incentives
  • marketing

Which of the following is NOT considered an orphan disease?

  • Crohn's disease
  • cystic fibrosis
  • Parkinson's disease
  • All of these are rare diseases.
  • None of these are rare diseases.

What condition may cause frequent lung infections, an inability to sweat and "reverse freckles"?

  • cystic fibrosis
  • Waardenburg syndrome
  • X-linked reticulate pigmentary disorder (XLPDR)

Which disease, which affects about 1 in 2 million people, is sometimes called stone man disease?

  • fibrodysplasia ossificans progressiva
  • metachromatic leukodystrophy
  • progressive supranuclear palsy

Which rare condition causes a person to begin rapidly aging as a child?

  • fibrodysplasia ossificans progressiva
  • Hutchinson-Gilford progeria syndrome
  • progressive multifocal leukoencephalopathy

How are most orphan diseases acquired?

  • from a virus
  • from mosquito bites
  • They're inherited.

How is an orphan disease defined under the Orphan Drug Act?

  • rare or neglected diseases
  • only inheritable diseases
  • diseases for which the cost of developing treatment isn't expected be recovered in sales

What is the characteristic symptom of the condition called Jumping Frenchmen of Maine?

  • depressed deep tendon reflexes
  • an extreme startle response
  • spasticity

What is the name of the disorder that causes blue skin and chocolate-colored blood?

  • medulloblastoma
  • methemoglobinemia
  • methionine adenosyltransferase I/III deficiency

How many orphan drugs have been developed as a result of the Orphan Drug Act of 1983?

  • none
  • fewer than 10
  • more than 250

What rare neurodegenerative disease did the 2014 Ice Bucket Challenge benefit?

  • arteriosclerosis
  • amyotrophic lateral sclerosis
  • multiple sclerosis
  • systemic sclerosis

Which adrenal condition may cause your skin to appear tan?

  • Addisonian anemia
  • Addison's disease
  • adenoameloblastoma

What percent of breast cancer diagnoses are male breast cancer?

  • zero
  • 1 percent
  • 3 percent

Which rare childhood neurodevelopmental disorder caught the world's attention when it was linked to the Zika virus in 2016?

  • macrocephaly
  • macrencephaly
  • microcephaly

Which fatal neurological disease are you probably safe from unless you eat human brains?

  • Creutzfeldt-Jakob disease
  • Gerstmann-Straussler-Scheinker disease
  • kuru

Which rare mental illness is sensationally known as "walking corpse syndrome"?

  • Capgras syndrome
  • Char syndrome
  • Cotard's delusion

True or false: You can literally be allergic to the cold.

  • true
  • false

Which condition, perhaps the most rare disease of them all, is named after the twins diagnosed with it?

  • Bright's disease
  • Fields condition
  • Lou Gehrig's disease

True or false: It's possible for a condition initially classified as "orphan" to outgrow that classification.

  • true
  • false

True or false: It's possible for a common condition to be reclassified as rare.

  • true
  • false

What does NORD stand for?

  • National Organization for Orphan and Rare Diseases
  • National Organization for Rare Disorders
  • National Organization for Rare Diseases
  • North American Organization for Rare Diseases

Which of the following incentives is available for orphan drug development?

  • clinical research subsidies
  • better patent protection
  • better marketing rights
  • tax incentives
  • All of these are offered.
  • Only the tax incentives are offered.

Devices intended for diagnosing or treating a condition that affects fewer than 4,000 Americans are called what?

  • Durable Humanitarian Device
  • Humanitarian Device Exemption
  • Humanitarian Use Device

When is Rare Disease Day observed?

  • last day of January
  • first day of February
  • last day of February