Rare Disease Quiz
by Staff
While each rare disease only affects a small number of people itself, rare diseases as a whole are a serious threat to public health. Learn a little about some diseases that may not get big headlines, but present global problems.

What is considered a "rare" disease?

  • a disease that affects fewer than 200,000 people
  • a disease without a cure
  • a disease that affects less than one in a million people

How many rare diseases are there?

  • 20000
  • 6800
  • 1400

What is another name for rare diseases?

  • unusual illness
  • orphan disease
  • standalone sickness

When was the last time a rare disease was discovered?

  • 2014
  • 2015
  • new, rare diseases are discovered every year

What are most rare diseases caused by?

  • the environment
  • genes
  • accidents

How many genes are in a human cell?

  • 17
  • 10000
  • 30000

A third of people with rare diseases take how long to get a diagnosis?

  • a year
  • a year to five years
  • They never get a correct diagnosis.

Why are rare diseases and drugs nicknamed "orphans?"

  • Pharmaceutical companies abandoned funding for them, due to the relative low profit from such a small patient group.
  • They were lonely.
  • They had no genetic "parent" disease.

What did the 1983 Orphan Drug Act do?

  • punished pharmaceutical companies
  • guaranteed access to drugs
  • created incentives and tax credits for research and manufacture of orphan drugs.

From 1973 to 1983, how many orphan drugs were developed with government assistance?

  • 450
  • 200
  • 10

After 1983, how many drugs have been developed?

  • 45
  • 250
  • 4000

Let's jump into some rare diseases to discover more about them. Speaking of jumping, what is the name of one rare disease?

  • Jumping Frenchman of Maine disease
  • Leaping Lords disease
  • Pouncing Cat disease

Some rare diseases are ones you actually might be familiar with. Which is NOT a rare disease?

  • cystic fibrosis
  • Lou Gehrig's disease
  • Alzheimer's disease

While we think of cancer as a common disease, there are many forms of rare cancers. What is one?

  • skin
  • lung
  • ovarian

Name the (real) rare disease.

  • Hurting Hands Disorder
  • Painful Legs and Moving Toes Syndrome
  • Awkward Movement and Flinching Pain Disorder

What cuddly acronym is given to a very not-cuddly rare disease?


What is another rare disease with a provocative name?

  • distant pancreas
  • wandering spleen
  • traveling throat

Let's see how good we are at medical terms. What is the clinical name when one of the blood vessels that supplies blood to the brain doesn't develop?

  • Internal carotid agenesis
  • neuro antihemo
  • brain vessel gone

Some rare diseases affect disparate parts of the body. What is one disease that causes abnormalities in different regions?

  • hand foot genital syndrome
  • thumb liver craniofacial syndrome
  • elbow knees and toes syndrome

Hantavirus is caused by what?

  • a genetic mutation
  • bad smog
  • contact with rodent saliva, urine or droppings

What is one rare disease named, due to an abnormality that gives the iris a "keyhole" appearance?

  • alien eye syndrome
  • cat eye syndrome
  • Margaret Keane syndrome

Parry Romberg syndrome causes what?

  • autoimmune weakening
  • small ears
  • atrophy of the facial skin, tissue and muscles

Autosomal dominant hyper IgE syndrome (AD-HIES) causes blisters, rashes and scaling of the skin. What was it formerly called?

  • snaking disorder
  • leprosy
  • Job syndrome

Kinky hair disease is now called Menkes disease, but it led to sparse, kinky hair. What caused it?

  • a genetic condition that affects copper levels in the body
  • too much protein
  • not enough calcium

Proteus syndrome causes what?

  • an ability to swim better
  • tumor growth and bone and skin abnormalities
  • webbed feet

Gigantism is caused by:

  • an overactive pituitary gland
  • overproduction of growth hormones
  • both

It has been speculated that Abraham Lincoln suffered from what rare disease?

  • Marfan Syndrome
  • MEN2B
  • both

Cold urticaria causes what?

  • an allergy to a sinus infection
  • a growth that increases with contact with the cold
  • an allergy to cold air or water

Rapid aging is seen in the rare disease:

  • maturation abundance
  • elderly growth syndrome
  • progeria

To raise awareness about rare diseases, the National Institutes of Health sponsors:

  • Rare Disease Day
  • a carnival
  • a Formula One racing team